Effects of Paraaminobenzene Sulfonamide on Oxygen Consumption

THE EFFECT OF PARA-AMINO BENZENE SULFONAMIDE ON THE OXYGEN CONSUMPTION OF TISSUE AND CERTAIN PATHOGENIC BACTERIA H. I. CHU and A. B. HASTINGS + Author Affiliations From the Department of Biological Chemistry, Harvard Medical School, Boston Abstract The effect of para-amino benzene sulfonamide on the oxygen consumption of rat liver and diaphragm, human blood, beta hemolytic streptococcus, gonococcus, pneumococci, types I and III, and meningococcus group I-III, was studied with the direct Warburg technique. With the exception of meningococcus, the drug at a concentration of 0.0132 gram per cent produced no effect. Increasing the drug concentration up to 0.660 gram per cent invariably reduced the oxygen uptake of the tissue as well as the bacteria. The effect of 0.132 gram per cent of the drug was variable.